【產(chǎn)品名稱】水飛薊賓
【英文別名】Flavobin;Silymarin I；Legalon
【IUPAC名稱】
（2R，3R）-3,5,7-三羥基-2 - [（2R，3R）-3-（4-羥基-3-甲氧基苯基）-2-（羥甲基）-2,3-二氫-1,4- -苯并二惡辛 -6-基] -2,3-二氫色烯-4-酮
【Isomeric SMILES】
COC1=C(C=CC(=C1)[C@@H]2[C@H](OC3=C(O2)C=C(C=C3)[C@@H]4[C@H](C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O
【CAS號】22888-70-6
【檢測方式】高效液相色譜法HPLC≥98%
【鑒定方法】液相（HPLC）質(zhì)譜（Mass) 核磁（NMR)
【作用與用途】本品用于含量測定、鑒別、藥理實驗、活性篩選等
【密度】1.569
【沸點】795.1°C
【藥理藥效】 水飛薊賓具有保護肝細(xì)胞免受毒素影響的保肝（抗肝毒性）特性。水飛薊賓還證實了對人前列腺腺癌細(xì)胞，雌激素依賴性和非依賴性人乳腺癌細(xì)胞，人宮頸癌細(xì)胞，人結(jié)腸癌細(xì)胞以及小和非人類肺癌細(xì)胞的體外抗癌作用
【穩(wěn)定性】本產(chǎn)品在正常的溫度和環(huán)境下比較穩(wěn)定
【生產(chǎn)單位】 成都普菲德生物技術(shù)有限公司
【質(zhì)量承諾】 非人為造成的產(chǎn)品質(zhì)量問題，我司負(fù)責(zé)退貨換貨
【溫馨提示】 我司提供一切產(chǎn)品僅供科研、實驗室使用，不得用于注射、食用或其他用途
苦參醇I|99119-69-4
異落新婦苷|54081-48-0
新異落新婦苷|54141-72-9
新落新婦苷|54081-47-9
苦參醇X|254886-77-6
苦參醇N|102490-65-3
苦參醇L|101236-50-4
苦參醇K|101236-49-1[1]. Woo SM, et al. Silibinin induces apoptosis of HT29 colon carcinoma cells through early growth response-1 (EGR-1)-mediated non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) up-regulation. Chem Biol Interact. 2014 Jan 16;211C:36-43.
[2]. Kim TH, et al. Silibinin induces cell death through ROS-dependent down-regulation of Notch-1/ERK/Akt signaling in human breast cancer cells. J Pharmacol Exp Ther. 2014 Jan 28.
[3]. Zhang S, et al. Silybin-mediated inhibition of Notch signaling exerts antitumor activity in human hepatocellular carcinoma cells. PLoS One. 2013 Dec 27;8(12):e83699.
[4]. Khan AQ, et al. Silibinin Inhibits Tumor Promotional Triggers and Tumorigenesis Against Chemically Induced Two-Stage Skin Carcinogenesis in Swiss Albino Mice: Possible Role of Oxidative Stress and Inflammation. Nutr Cancer. 2013 Dec 23.
[5]. Khazim K, et al. The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo. Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F691-700.
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